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Proposed structure of ITK. (A) Structural domains of ITK. (B) Structural domains of SLP-76, including those sites implicated in interactions with Vav, ITK, PLC-γ1, and Gads. (C) Intramolecular folded conformation of inactive ITK. (D) Alternative head-to-tail dimer of inactive ITK. (E) Relationship between SLP-76 and ITK and the resulting effect on the kinase activity of ITK.
