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. Author manuscript; available in PMC: 2010 Aug 1.
Published in final edited form as: Am J Transplant. 2009 Jun 16;9(8):1773–1783. doi: 10.1111/j.1600-6143.2009.02706.x

Figure 6. Neutralizing IL-6 reduces cardiac fibrosis.

Figure 6

(A) Representative views of Masson’s trichrome staining of day 30 post transplant cardiac allografts taken from recipients transiently depleted of CD4+ cells which also received either control rat IgG antibodies (Anti-CD4 + Rat IgG) or neutralizing IL-6 mAb (Anti-CD4 + Anti-IL-6). (B) Morphometric analysis of graft fibrosis in groups described in (A). Bars represent the combined mean + S.E.M. of fibrotic (blue) area from at least 10 different frames of view from each of at least 6 different cardiac grafts. (C) Intragraft collagen αI message levels in cardiac allografts taken from recipients described in (B) were determined using quantitative real time PCR. Bars represent mean + S.E.M. of tissue harvested from at least 6 different transplants per group.