Skip to main content
. Author manuscript; available in PMC: 2010 Aug 1.
Published in final edited form as: Am J Transplant. 2009 Jun 16;9(8):1773–1783. doi: 10.1111/j.1600-6143.2009.02706.x

Figure 7. Neutralizing IL-6 ameliorates contractile parameter aberrations associated with CR.

Figure 7

Serial echocardiography was used to monitor anatomical and functional parameters in cardiac allograft recipients that were transiently depleted of CD4+ cells which also received neutralizing IL-6 mAb (Anti-CD4 + Anti-IL-6, circles). Results are plotted against 3 recipients that were transiently depleted of CD4+ cells (Anti-CD4, squares) from Figure 2. Echocardiographic parameters included posterior wall thickness (PWT) (A), fractional shortening (FS) (B), and left ventricle ejection fraction (LVEF) (C). For the anti-IL-6 mAb treated group, 5 transplants were followed throughout the duration of the experiment. Individual points represent mean and bars represent ± S.E.M. of grafts analyzed at the given time point.