Table 1. Regions showing significant s in functional brain activation in response to acute colorectal distension (60-mmHg) compared to 0-mmHg controls in female and male rats.
| Brain region | 60- vs. 0-mmHg (Left / Right) |
|
|---|---|---|
| Female | Male | |
| Cerebral cortex | ||
| Auditory (Au) | + / + | + / + |
| Cingulate, dorsal anterior (Cg1) | - / - | + / + |
| ventral anterior (Cg2) | / + | -/ - |
| Ectorhinal (Ect) | + / + | |
| Infralimbic (IL) | + / + | |
| Insular, anterior (aIns) | + / + | |
| mid/posterior dysgranular (pIns) | / + | + / + |
| Motor, primary (M1) | + / + | |
| secondary (M2) | - / - | + / + |
| Orbital, lateral, ventral (LO, VO) | - / - | |
| Parietal, association (PtA) | - / - | + / + |
| Piriform (Pir) | + / + | |
| Prelimbic (PrL) | + / + | |
| Somatosensory, primary, barrel field (S1BF) | + / + | |
| forelimb (S1FL) | + / + | |
| hindlimb (S1HL) | + / + | |
| trunk (S1Tr) | / - | + / + |
| Somatosensory, secondary (S2) | - / - | + / + |
| Temporal association (TeA) | + / + | + / + |
| Visual, primary (V1) | + / + | |
| secondary (V2) | + / + | |
| Subcortical regions | ||
| Accumbens n., core, shell (Acb) | + / + | |
| Amygdala, cortical, basomedial, medial (AA, ACo, BMA, MeA) | + / + | |
| central n., amygdalostriatal transition area (CeA, AStr) | + / + | + / + |
| lateral n.(LaA) | + / | + / + |
| Anterior pretectal area (APT) | + / + | |
| Caudate putamen, ventral posterior (vCPu) | + / + | |
| dorsal anterior (dCPu) | - / - | + / + |
| lateral (lCPu) | - / - | |
| Endopiriform n., dorsal, intermed (DEn, IEn) | + / + | |
| Gigantocellular reticular n. (Gi) | + / + | |
| Globus pallidus, external (EGP) | + / + | |
| internal (IGP) | + / + | |
| Habenula (Hb) | + / + | |
| Hippocampus, CA1-3, anterior | - / - | |
| CA1, posterior | - / | - / |
| Hypothalamus, medial preoptic (MnPO) | + / + | |
| posterior, dorsomedial (PH, DM) | - / - | |
| peduncular part of lateral (PLH) | - / - | - / - |
| Inferior colliculus (IC) | + / + | + / + |
| Interpeduncular n. (IP) | + | |
| Interstitial nucleus of Cajal (InC) | + / + | |
| Locus coeruleus (LC) | + / + | |
| Parabrachial, pigmented n. of the VTA, lateral n., medial n. (PBP, LPB, MPB) | + / + | - / - |
| Periaqueductal gray (PAG) | - / - | |
| Pontine reticular nucleus, caudal (PnC) | + / + | - / - |
| Raphe, dorsal, median, paramedian, interpositus n., rost linear (DR, MnR, PMnR, RIP, RLi) | + | |
| Red nucleus (RN), pararubral n. (PaR), prerubral field (PR) | + / + | - / - |
| Reticular n., intermediate (Irt) | + / + | |
| Subbrachial n. (SubB) | + / + | |
| Substantia nigra (SN) | + / + | - / - |
| Superior colliculus (SC) | + / + | - / - |
| Thalamus, lateral geniculate (LG) | + / + | - / - |
| medial geniculate (MG) | + / + | |
| mediodorsal (MD) | + / + | |
| ventroposterior (VPM,VPL) | + / + | - / - |
| ventrolateral, ventral anterior (VL, VA) | - / - | |
| ventromedial nucleus (VM) | - / - | - / - |
| posterior group (Po, PoT) | + / + | - / - |
| anterior nuclei (anterodorsal, AD; anteroventral, AV; anteriomedial, AM) | - / - | |
| midline nuclear group (paraventricular, PVA, paratenial, PT; reuinens, Re; rhomboidal, Rh; submedius, Sub) | - / - | |
| Trigeminal nucleus, sensory, lateral (Pr5) | + / + | - / |
| Ventral tegmental area, rostral (VTAR) | + / + | |
Significant increases or decreases are noted with ‘+’ and ‘-’, respectively. Significance is shown at the voxel level (P < 0.05) for clusters of >100 contiguous voxels. Male results were reproduced from Wang et al. [52] with permission. Abbreviations are taken from the Paxinos and Watson (2005) rat atlas [35].