Table 5.
Pedigree-Based Association Test for IREB2 SNPs with Postbronchodilator FEV1 in ICGN Families
| SNP | Minor Allele | MAF for ICGN | Risk Allele | Informative Families for PBAT Analysis for ICGN | ICGN p Value for Postbronchodilator FEV1 | NETT-NAS p Value for Case-Control Status | BEOCOPD p Value for Postbronchodilator FEV1 | Combined p Value: Fisher Method a |
|---|---|---|---|---|---|---|---|---|
| rs2568494 | A | 0.42 | A | 479 | 1.64 × 10−3 | 4.40 × 10−5 | 9.25x10−3 | 1.64 × 10−7 |
| rs2656069 | C | 0.19 | T | 386 | 0.02 | 1.03 × 10−5 | 0.35 | 1.03 × 10−5 |
| rs1964678 | A | 0.35 | G | 484 | 5.84 × 10−3 | 1.61 × 10−3 | 0.76 | 5.94 × 10−4 |
| rs12593229 | T | 0.35 | G | 481 | 4.68 × 10−3 | 2.95 × 10−3 | 0.87 | 9.21 × 10−4 |
| rs10851906 | G | 0.19 | A | 384 | 0.02 | 2.46 × 10−5 | 0.21 | 1.65 × 10−5 |
| rs965604 | G | 0.35 | A | 483 | 4.71 × 10−3 | 1.81 × 10−3 | 0.75 | 5.42 × 10−4 |
| rs13180 | C | 0.36 | T | 467 | 5.07 × 10−3 | 2.17 × 10−3 | 0.71 | 6.42 × 10−4 |
MAF denotes minor allele frequency.
a
Same direction of effect for the risk alleles.