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. Author manuscript; available in PMC: 2010 Apr 29.
Published in final edited form as: J Am Chem Soc. 2009 Apr 29;131(16):5792–5799. doi: 10.1021/ja809554x

Scheme 7. Coupling of the dodecasaccharide with the 20–27aa domain of hFSH β-subunit.

Scheme 7

aReagents and Conditions: (a) H-Trp(SEt), EDC, HOOBt, TFE/CHCl3 (1:3); (b) TFA, PhOH, TIPS, H2O; 21% from 25; (c) IIa, HATU, DIEA, DMSO, ca. 25–35%.