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. Author manuscript; available in PMC: 2009 Nov 7.
Published in final edited form as: Nature. 2009 Mar 8;459(7243):113–117. doi: 10.1038/nature07861

Figure 1. Drosophila Asf1 promotes H3 K56 acetylation, while CAF-1 deposits H3 K56Ac into chromatin.

Figure 1

a and b H3 K56ac levels in chromatin after DNA damage. c. Asf1 is required for H3 K56 acetylation, and in response to DNA damage, d. e. H3 K56Ac levels on chromatin following CAF-1 p180 knockdown. f. H3 K56Ac levels in free histones in the supernatant (“S”) and chromatin bound pellet (“P”). * indicates a likely proteolytic product of H3. g. Drosophila embryos were stained with no primary antibody (“no Ab”), antisera to Asf1 or K56Ac, as indicated. Secondary antibody was included in all analyses