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. Author manuscript; available in PMC: 2009 Nov 7.
Published in final edited form as: Nature. 2009 Mar 8;459(7243):113–117. doi: 10.1038/nature07861

Figure 2. Drosophila CBP acetylates H3 K56, while Sir2 deacetylates H3 K56Ac in vivo.

Figure 2

a. Inhibition of CBP by curcumin lowers levels of H3 K56Ac in S2 cells. Duplicate analyses are shown. b. CBP acetylates H3 K56. c. CBP is required for the increase of H3 K56Ac on chromatin after DNA damage. d. Inhibition of NAD-dependent HDACs by nicotinamide increases K56Ac. e. Sir2 deacetylates H3 K56Ac.