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. Author manuscript; available in PMC: 2009 Nov 7.
Published in final edited form as: Nature. 2009 Mar 8;459(7243):113–117. doi: 10.1038/nature07861

Figure 3. Human CBP/p300 acetylates H3 K56 while SirT1 and SirT2 deacetylate H3 K56Ac.

Figure 3

a. Levels of H3 K56Ac on human chromatin following gamma irradiation. b. H3 K56Ac localizes to DNA damage foci. c. HU, MMS and UV induce H3 K56Ac. d. CBP/p300 are required for acetylation of H3 K56 in the absence and presence, e, of DNA damage. f. Human CBP and p300, g, acetylate H3 K56 in vitro. h. Inhibition of NAD-dependent HDACs increases H3 K56Ac levels. i. Human SirT2 and SirT1 deacetylate H3 K56Ac in vivo. j. Human SirT2 and SirT1 deacetylate H3 K56Ac in vitro.