Table 2.
Relative risks of Sudden Arrhythmic Death during Follow-up, According to Quartile of Plasma Biomarker Levels at Baseline
| Quartiles of Plasma Level |
|||||
|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | P for trend | |
| NT-proBNP | |||||
| Median (pg/mL) | 32.5 | 61 | 102.5 | 235 | |
| Quartile range- | 6 – 44 | 45 – 78 | 79 – 146 | 148 – 3126 | |
| Model 1 (age, fasting) * | 1.0 | 1.08 (0.53 –2.19) | 1.33 (0.65 –2.74) | 1.66 (0.79 –3.47) | 0.15 |
| Multivariable Model 2† | 1.0 | 1.34 (0.61 – 2.97) | 1.37 (0.61 – 3.08) | 2.07 (0.88 – 4.88) | 0.10 |
| Multivariable Model 3‡ | 1.0 | 1.33 (0.58 – 3.02) | 1.34 (0.58 – 3.10) | 2.37 (0.97 – 5.80) | 0.05 |
| hsCRP | |||||
| Median (mg/L) | 0.68 | 1.99 | 4.61 | 9.34 | |
| Quartile range- | 0.27 – 1.21 | 1.22 – 3.06 | 3.08 – 6.45 | 6.59 – 143 | |
| Model 1* | 1.0 | 1.31 (0.65 –2.61) | 1.43 (0.72 –2.86) | 1.91 (0.97–3.77) | 0.06 |
| Multivariable Model 2† | 1.0 | 1.07 (0.49 – 2.35) | 1.09 (0.48 – 2.49) | 1.32 (0.58 – 3.02) | 0.46 |
| Multivariable Model 3‡ | 1.0 | 1.18 (0.51 – 2.72) | 1.10 (0.46 – 2.65) | 1.30 (0.54 – 3.14) | 0.60 |
| Total Cholesterol-HDL Ratio | |||||
| Median- | 2.67 | 3.28 | 3.82 | 4.73 | |
| Quartile range- | 1.67 – 3.06 | 3.06 – 3.55 | 3.56 – 4.20 | 4.20 – 8.00 | |
| Model 1* | 1.0 | 1.18 (0.59 –2.34) | 0.92 (0.45 –1.90) | 1.56 (0.82 –2.98) | 0.18 |
| Multivariable Model 2† | 1.0 | 1.26 (0.58 – 2.76) | 1.04 (0.46 – 2.36) | 1.15 (0.51 – 2.58) | 0.89 |
| Multivariable Model 3‡ | 1.0 | 1.01 (0.42 – 2.43) | 1.38 (0.54 – 3.53) | 1.34 (0.49 – 3.66) | 0.50 |
| LDL-cholesterol | |||||
| Median (mg/dL) | 108.5 | 139 | 160 | 190.5 | |
| Quartile range- | 49 – 123 | 124 – 149 | 150 – 173 | 174 – 296 | |
| Model 1* | 1.0 | 1.92 (0.97 –3.80) | 1.46 (0.70 –3.03) | 1.79 (0.87 –3.68) | 0.22 |
| Multivariable Model 2† | 1.0 | 1.63 (0.76 – 3.51) | 1.44 (0.62 – 3.35) | 1.36 (0.59 – 3.13) | 0.66 |
| Multivariable Model 3‡ | 1.0 | 1.37 (0.59 – 3.20) | 1.66 (0.66 – 4.20) | 1.36 (0.53 – 3.51) | 0.57 |
| Triglycerides | |||||
| Median (mg/dL) | 82 | 122 | 166 | 239 | |
| Quartile range- | 7 – 101 | 102 – 141 | 142 – 193 | 194 – 759 | |
| Model 1* | 1.0 | 1.02 (0.51 –2.04) | 1.05 (0.51 –2.18) | 1.66 (0.84 –3.28) | 0.10 |
| Multivariable Model 2† | 1.0 | 0.90 (0.43 – 1.91) | 0.87 (0.39 – 1.97) | 1.52 (0.71 – 3.25) | 0.19 |
| Multivariable Model 3‡ | 0.85 (0.37 – 1.93) | 0.81 (0.32 – 2.03) | 1.46 (0.56 – 3.83) | 0.31 | |
| HDL-cholesterol | |||||
| Median (mg/dL) | 49 | 59 | 68 | 82.5 | |
| Quartile range- | 24 – 54 | 55 – 62 | 63 – 73 | 74 – 135 | |
| Model 1* | 1.0 | 0.66 (0.34 –1.31) | 0.89 (0.48 –1.65) | 0.92 (0.49 –1.72) | 0.95 |
| Multivariable Model 2† | 1.0 | 0.72 (0.35 – 1.51) | 1.03 (0.51 – 2.10) | 1.29 (0.61 – 2.73) | 0.40 |
| Multivariable Model 3‡ | 1.0 | 0.81 (0.37 – 1.76) | 1.08 (0.49 – 2.39) | 1.25 (0.53 – 2.93) | 0.53 |
Model 1: Controlled simultaneously for age and fasting status
Multivariable Model 2: Controlled for variables listed above in Model 1 and history of hypertension, history of diabetes, alcohol consumption (<0.1 g, 0.1–14.9, 15.0 to 29.9, 30+), parental history of myocardial infarction prior to age 60, body-massindex (<25 kg/m2, 25–30 kg/m2, >=30 kg/m2), physical activity (quintiles of metabolic equivalent (MET-hours)), current postmenopausal hormone use, GFR, and aspirin use>=22 days/month.
Multivariable Model 3: Controlled for variables listed above in multivariable Model 2 and simultaneously for plasma NT-proBNP, hsCRP, triglyceride, and TC/HDL-Ratio levels.