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. Author manuscript; available in PMC: 2009 Oct 5.
Published in final edited form as: Drug Dev Ind Pharm. 2009 May;35(5):515–524. doi: 10.1080/03639040802488097

Figure 5.

Figure 5

Schematic depicting the physical disposition of SPL7013 dendrimer in Prototype Combination Vaginal Gels before ultracentrifugation (A), and after ultracentrifugation (B,C). Ultracentrifugation of the viscous Carbopol-based gel produces a water-rich band (“Water Band”) on top and a gel-rich band (“Gel Band”) on the bottom of the tube. B shows a water band with equal concentration of SPL7013 in the Water Band and the Gel Band as would be expected in the absence of sequestration. C shows a water band with reduced SPL7013 concentration as would be expected if SPL7013 dendrimer were sequestered by the Carbopol-based gel.