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. Author manuscript; available in PMC: 2009 Oct 5.
Published in final edited form as: Drug Dev Ind Pharm. 2009 May;35(5):515–524. doi: 10.1080/03639040802488097

Table 1.

Compositions of BufferGel and VivaGel, and Target Composition for Novel Prototype Combination Vaginal Gels (Prototypes 1 and 2) Containing SPL7013 Dendrimer

Ingredient
(all values in % w/w)		 BufferGel VivaGel Target Prototype
Combination
Vaginal Gels
Mucoadhesive/
Thickening/
Buffering agent		 Carbopol 974P 5.0% Carbopol 971P Carbopol 974P or 971P
pH adjustment Dibasic potassium
phosphate		 9% 2N Sodium hydroxide KOH
Preservative Sorbic acid 0.18% methyl paraben and
0.02% propyl paraben		 0.18% methyl paraben and
0.02% propyl paraben
Osmolality
adjustment		 Monobasic Sodium
Phosphate		 None None
Antioxidant EDTA disodium 0.1% EDTA disodium 0.15% EDTA disodium
Emollient None 1.0% propylene glycol and
1.0% glycerin		 None
Viscosity reducer Magnesium sulfate None Not needed due to Na
from Na SPL7013
Inactivation of bacterial
pathogens (GC and BV)		 None None Lactic and acetic acids
SPL7013 Dendrimer (active) None 3% 3%