Table 3.

Concentration of SPL7013 Dendrimer in Water-Band and Gel-Band after Ultracentrifugation of 3% w/w Prototype 1 and Prototype 2 Vaginal Gels at 50,000 rpm for 30 min

			SPL7013 Concentration (% w/w) (n=6)
Material			Water-Band	Gel-Band
SPL7013
Aqueous solution, untreated control			3.00 ± 0.03	N/A
Aqueous solution, ultracentrifuged			2.97± 0.01	N/A
Prototype 1 Vaginal Gel
Control, untreated			3.03 ± 0.01	3.03 ± 0.01
Ultracentrifuged			4.54 ± 0.07	2.67 ± 0.06
Prototype 2 Vaginal Gel
Control, untreated			3.00 ± 0.02	3.00 ± 0.02
Ultracentrifuged			4.46 ± 0.03	2.49 ± 0.01
	Viscosity (cP)	pH
VivaGel
Ultracentifuged	10,183	4.80	No Band	3.00 ± 0.05
Ultracentrifuged
after diluting 10% with water	8,830	4.47	No Band	2.74 ± 0.11
after diluting 5% with water	9,525	4.37	No Band	2.87 ± 0.06
after diluting 2.5% with water	9,872	4.34	No Band	2.91 ± 0.04
after diluting 10% with 6N HCl	695	0.66	2.93 ± 0.10	3.56 ± 0.26
after diluting 5% with 6N HCl	2,009	1.22	2.90 ± 0.08	3.48 ± 0.11
after diluting 2.5% with water	3,188	1.96	2.84 ± 0.07	3.29 ± 0.12
after diluting 10% with 5M NaCl	2,914	4.27	3.67 ± 0.08	2.46 ± 0.16
after diluting 5% with 5M NaCl	3,237	4.23	3.50 ± 0.09	2.62 ± 0.06
after diluting 2.5% with 5M NaCl	6,598	4.21	No Band	2.97 ± 0.11