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. Author manuscript; available in PMC: 2010 Aug 1.
Published in final edited form as: Curr Opin Cell Biol. 2009 May 13;21(4):516–521. doi: 10.1016/j.ceb.2009.04.006

Fig. 1. Degradation of ERAD-L, -M, and —C substrates.

Fig. 1

Soluble and integral membrane proteins with mis-folding lesions in the lumen, and integral membrane proteins with mis-folding lesions within the membrane and in the cytoplasmic space are depicted. In nearly all cases, substrates are delivered to the proteasome for degradation in a process that requires the p97 complex (also known as the Cdc48 complex in yeast).