Table 1.

Individual drug dosing recommendations by kidney function

Drug	Levels of Dosing	CCr Range	Recommended Dose (Route)
Enoxaparin 28	2	≥30	40 mg every day (subcutaneous)
		<30	30 mg every day
Eptifibatide 28	2	≥50	2.0 mcg/kg/min (intravenous)
		<50	1.0 mcg/kg/min
Ranitidine 28	2	≥50	150 mg twice a day (by mouth)
		<50	150 mg every day
Acyclovir 28	3	>25	800 mg every 4 hrs (by mouth)
		10–25	800 mg every 8 hrs
		<10	800 mg every 12 hrs
Atenolol 29	3	>35	50–100 mg every day (by mouth)
		15 to 35	50 mg every day
		<15	25 mg every day
Cefazolin 30	3	>35	1 g every 8 hrs (intravenous)
		11 to 35	1 gm every 12 hrs
		≤10	500 mg every day
Digoxin 31	3	>50	every 24 hrs (by mouth)
		10 to 50	25% to 75% of dose or every 36 hrs
		<10	10% to 25% of dose or every 48 hrs
Levofloxacin 28	3	≥50	500 mg every day (by mouth)
		20 to 49	250 mg every day
		<20	250 mg every 2 days
Tenofovir 28	3	≥50	300 mg every day (by mouth)
		30 to 49	300 mg every 48 hrs
		<30	300 mg twice weekly
Tramadol 32	3	>30	50–100 mg every 6 hrs (by mouth)
		10 to 30	50–100 mg every 12 hrs
		<10	50 mg every day
Allopurinol 31	4	>90	300 mg every day (by mouth)
		50 to 90	75% of dose
		10 to 49	50% of dose
		<10	25% of dose
Gabapentin 33	4	>60	300–1200 mg 3 times a day (by mouth)
		30 to 60	200–700 mg twice a day
		15 to 29	200–700 mg every day
		<15	100–300 mg every day
Sotalol 34	4	≥60	80–160 mg every 12 hrs (by mouth)
		30–59	80–160 mg every day
		10 to 29	80–160 mg every 36–48 hrs
		<10	‘Not recommended'
Disopyramide 35	5	>90	150 mg every 6 hrs (by mouth)
		41 to 90	100 mg every 6 hrs
		31 to 40	100 mg every 8 hrs
		15 to 30	100 mg every 12 hrs
		<15	100 mg every day
Lamivudine 28	5	>50	150 mg twice a day (by mouth)
		30 to 50	150 mg every day
		15 to 29	100 mg every day
		5 to 14	50 mg every day
		<5	25 mg every day

Abbreviation: CCr, creatinine clearance