Figure 2.

CPMs in Mrgprd ^−/− mice exhibit decreased mechanical sensitivity. Sharp electrode recordings were made from WT (black), Mrgprd ^+/+ (white), and Mrgprd ^−/− (gray) CPM cells that were tested for their response to mechanical stimuli. A–C, No significant difference was observed between the mice in either the average mechanical threshold (A; millinewtons) or in the mean peak instantaneous frequency (B; hertz); however, the mean rate for multiple force stimuli (C; spikes per second; 5, 10, 25, 50, and 100 mN) were decreased in the Mrgprd ^−/− mice. Significance (p < 0.05) is indicated below Mrgprd ^−/− in relation to either just WT (*) or to both WT and Mrgprd ^+/+ (**).