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CPMs in Mrgprd −/− mice exhibit decreased cold sensitivity. Sharp electrode recordings were made from WT (black), Mrgprd +/+ (white), and Mrgprd −/− (gray) CPM cells that were tested for their response to cold stimuli. Mrgprd −/− CPM cells had lower cold thresholds (A; degrees Celsius) but maintained a similar peak instantaneous frequency (B; hertz) compared with Mrgprd +/+ mice. *p < 0.05.
