Table 2.
Deletion of Mrgprd reduces DRG neuron excitability and abolishes sensitivity to 1 mm β-alanine
| Genotype |
I
th (pA) |
APs at I
th
|
||||
|---|---|---|---|---|---|---|
| Control | β -Alanine | p value | Control | β -Alanine | p value | |
| +/− | 103.5 ± 17.4 | 70 ± 10.0 | 0.006 | 1.1 ± 0.1 | 3.2 ± 0.5 | 0.0002 |
| −/− | 183.5 ± 27.9 | 196 ± 29.3 | N.S. | 1.1 ± 0.1 | 0.9 ± 0.2 | N.S. |
| p value | 0.02 | 0.0002 | ||||
Ith, Threshold current to generate one AP, determined using whole-cell patch-clamp electrophysiology; n = 20 GFP+ neurons per genotype. Data are presented as means ± SEM. p values from paired t test are shown. N.S., Not significant (p > 0.05)