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. Author manuscript; available in PMC: 2009 Oct 5.
Published in final edited form as: Adv Synth Catal. 2008 May 5;350(7-8):1023–1045. doi: 10.1002/adsc.200800017

Table 3.

Evaluation of ligand structure in additions of MeLi to imine 8

graphic file with name nihms91828u3.jpg
entry R3 ligand temp, °C yield, %a erb
1 Me 12ac −75c 90 83.5:16.5
2 Et 12bc −78 95 87.5:12.5
3 CH2CHMe2 12cc −78 65 92.0:8.0
4 CH2CHMe2 12cc −63 95 92.5:7.5
5 CH2(Me)c-Pr 12jc −75c 85 92.6:7.4
6 CHMe2 12ec −75c 87 94.5:5.5
7 Me, CHMe2 12dc −75c 97 87.0:13.0
a

Yield of chromatographically homogeneous material.

b

All compounds have R configuration. Determined by CSP-HPLC analysis.

c

Internal temperature.