Table 5.

Evaluation of ligand structure in additions of MeLi to imine 10

entry	R3	ligand	temp, °C	yield, %a	erb
1	Me	12ac	−75c	73	97.0:3.0
2	Et	12bc	−78	65	91.5:8.5
3	Et	12bc	−63	79	92.5:7.5
4	Et	12bc	−41	90	89.5:10.5
5	CH2CHMe2	12cc	−41	90	86.5:13.5
6	CH2(Me)c-Pr	12jc	−75c	87	89.0:11.0
7	CHMe2	12ec	−75c	77	90.5:9.5

^aYield of analytically pure material.

^bAll compounds have R configuration. Determined by CSP-HPLC analysis.

^cInternal temperature.