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Examples of biological consequences of protein deformation. Mechanical forces can (a) switch a ‘lid’ in a protein from ‘close’ to ‘open’ position, or (b) unfold a protein domain, thus exposing the ligand binding site. Protein deformation could also (c) expose the nonpolar residues, causing non-specific interaction between the protein domain and other biomolecules; or (d) induce a change in binding affinity, altering protein-protein interactions
