. Author manuscript; available in PMC: 2009 Oct 5.

Published in final edited form as: Exp Mech. 2009 Feb 1;49(1):153–164. doi: 10.1007/s11340-008-9154-0

Table 1.

Structural features of key force sensing or bearing proteins

Protein	Class	Superfamily	Fold
Fibronectin type III domain, tenascin, type I titin, integrin beta-4 subunit	All beta proteins	Fibronectin type III	Immunoglobulin-like beta-sandwich: sandwich; seven strands in two sheets
VCAM-1, ICAM-1, ICAM-2	All beta proteins	Immunoglobulin	Immunoglobulin-like beta-sandwich: sandwich; seven strands in two sheets
von Willebrand factor A1 domain, von Willebrand factor A3 domain	Alpha and beta proteins (a/b)	vWA-like	vWA-like: mainly parallel beta sheets (beta-alpha-beta units)
Integrin alpha1-beta1, integrin alpha2- beta1, integrin alpha-x beta2, integrin beta A domain, integrin alpha M, integrin CD11a/CD18
Integrin beta-3	Small proteins	Plexin repeat	Trefoil/plexin domain-like: disulfide- rich fold; common core is alpha+beta with two conserved disulfides