Table 4.
Stratified analysis for XRCC3 T241M and TP53 R72P by ethnicity, smoking status, and histology
| Gene variant | No. studies | No. cases | No. controls | Heterozygotes OR (95% CI) | Homozygotes OR (95% CI) | Per allele OR (95% CI) | Ptrend | Pheterogeneity |
|---|---|---|---|---|---|---|---|---|
| XRCC3 T241M | ||||||||
| Ethnicity | ||||||||
| Non-Hispanic Whites* | 5 | 3,042 | 4,644 | 0.89 (0.80–0.99) | 0.84 (0.71–1.00) | 0.91 (0.84–0.98) | 0.01 | 0.54 |
| Asian* | 3 | 425 | 377 | 0.82 (0.49–1.37) | 0.92 (0.12–6.98) | 0.84 (0.48–1.49) | 0.55 | 0.22 |
| Smoking | ||||||||
| Never† | 6 | 477 | 1,951 | 1.03 (0.78–1.36) | 1.28 (0.86–1.92) | 1.10 (0.91–1.33) | 0.32 | 0.50 |
| Ever* | 7 | 2,985 | 3,062 | 0.85 (0.76–0.96) | 0.78 (0.65–0.94) | 0.87 (0.80–0.95) | 0.002 | 0.73 |
| Former* | 5 | 686 | 1,410 | 0.79 (0.63–0.98) | 0.77 (0.55–1.09) | 0.86 (0.73–1.00) | 0.05 | 0.93 |
| Current* | 5 | 2,229 | 1,587 | 0.91 (0.78–1.05) | 0.80 (0.54–1.20) | 0.90 (0.79–1.03) | 0.11 | 0.32 |
| Histology | ||||||||
| Squamous cell* | 5 | 1,350 | 3,832 | 0.88 (0.71–1.11) | 0.78 (0.62–0.99) | 0.90 (0.74–1.08) | 0.24 | 0.14 |
| Small cell* | 4 | 414 | 3,426 | 0.84 (0.66–1.08) | 0.66 (0.44–0.98) | 0.83 (0.70–0.98) | 0.03 | 0.82 |
| Adenocarcinoma* | 6 | 935 | 4,741 | 0.88 (0.74–1.05) | 1.04 (0.80–1.34) | 0.98 (0.87–1.10) | 0.72 | 0.87 |
| Gender | ||||||||
| Male‡ | 7 | 2,546 | 3,348 | 0.87 (0.76–0.99) | 0.83 (0.69–1.01) | 0.90 (0.82–0.98) | 0.02 | 0.49 |
| Female‡ | 7 | 851 | 1,664 | 0.91 (0.74–1.13) | 0.90 (0.64–1.26) | 0.94 (0.81–1.10) | 0.44 | 0.44 |
| TP53 R72P | ||||||||
| Ethnicity | ||||||||
| Non-Hispanic Whites* | 5 | 3,159 | 4,605 | 1.14 (0.94–1.39) | 1.19 (0.97–1.45) | 1.12 (0.99–1.26) | 0.07 | 0.20 |
| Asian* | 2 | 232 | 332 | 1.30 (0.87–1.95) | 1.46 (0.87–2.47) | 1.23 (0.95–1.59) | 0.92 | 0.85 |
| Smoking | ||||||||
| Never† | 6 | 424 | 2,082 | 1.16 (0.91–1.48) | 0.96 (0.64–1.43) | 1.03 (0.87–1.22) | 0.69 | 0.59 |
| Ever* | 5 | 3,181 | 3,203 | 1.17 (0.96–1.41) | 1.37 (1.05–1.77) | 1.18 (1.03–1.35) | 0.017 | 0.11 |
| Former* | 5 | 929 | 1,804 | 1.23 (1.03–1.48) | 1.37 (1.02–1.85) | 1.19 (1.05–1.36) | 0.007 | 0.42 |
| Current* | 4 | 2,251 | 1,397 | 1.11 (0.83–1.49) | 1.42 (0.83–2.42) | 1.17 (0.91–1.50) | 0.20 | 0.03 |
| Histology | ||||||||
| Squamous cell* | 5 | 1,296 | 4,466 | 1.26 (1.04–1.52) | 1.52 (1.19–1.94) | 1.22 (1.10–1.35) | <0.001 | 0.59 |
| Small cell* | 3 | 376 | 3,635 | 0.81 (0.63–1.05) | 1.27 (0.68–2.37) | 0.96 (0.80–1.15) | 0.64 | 0.41 |
| Adenocarcinoma* | 6 | 1,061 | 5,294 | 1.05 (0.90–1.22) | 1.00 (0.77–1.29) | 1.02 (0.91–1.14) | 0.75 | 0.60 |
| Gender | ||||||||
| Male‡ | 5 | 2,495 | 3,307 | 1.09 (0.96–1.23) | 1.30 (1.05–1.60) | 1.12 (1.02–1.22) | 0.01 | 0.49 |
| Female‡ | 6 | 1,115 | 1,987 | 1.14 (0.95–1.36) | 1.10 (0.83–1.46) | 1.08 (0.95–1.22) | 0.25 | 0.75 |
*
OR adjusted for age, sex, tobacco cumulative exposure (pack-years), and country when applicable.
†
OR adjusted for age, sex, and country when applicable.
‡
OR adjusted for age, tobacco cumulative exposure (pack-years) and country when applicable.