. Author manuscript; available in PMC: 2010 Jun 1.

Published in final edited form as: Semin Cell Dev Biol. 2009 Feb 13;20(3):321–329. doi: 10.1016/j.semcdb.2009.02.002

Table 1.

Examples of redox-regulated signal transduction pathways

Pathway	Endogenous source of ROS	Redox sensors/linkages	References
Wnt/beta-catenin	N.D.	NRX/dsh	[37]
Integrin/Rac	Mitochondria	N.D.	[108]
RTK/Ras/MAPK	NADPH oxidases, Mitochondria	Tyrosine kinases^, MAPKs (p38, JNK, ERK)^	[38, 39, 109]
RTK/PI3K/AKT	Mitochondria	PTEN	[5]
JAK/STAT	N.D.	CaMKII, JAK2	[32, 110, 111]
Notch	Mitochondria	PHD/HIF-1α, FIH-1/NICD	[68, 69]

probably via redox-sensitive phosphatases

N.D., not determined