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. Author manuscript; available in PMC: 2009 Oct 5.
Published in final edited form as: Nat Neurosci. 2008 Oct 5;11(11):1302–1310. doi: 10.1038/nn.2204

Figure 6. Alterations in dendritic complexity in the HPC of mutant mice.

Figure 6

(a) Representative tracings of the basal dendritic tree of pyramidal neurons from the CA1 region of the HPC of Df(16)A+/−;Thy1-GFP+/− and WT Thy1-GFP+/− mice.

(b) Reduction in the total number of branchpoints of basal dendrites in Df(16)A+/−;Thy1-GFP+/− CA1 hippocampal neurons relative to WT Thy1-GFP+/− CA1 neurons.

(c) Sholl analysis of dendritic complexity using 10 µm concentric circles around the soma. A repeated measures ANOVA examining the interaction between branchpoints and distance from the soma shows an overall genotype effect indicating a significant reduction in branching prevalent throughout the dendritic tree (n = 18, P < 0.008).

(d) Representative tracings of the basal dendritic tree of pyramidal neurons from the CA1 region of the HPC of Zdhhc8+/+;Thy1-GFP+/–, Zdhhc8+/–;Thy1-GFP+/− and Zdhhc8−/− ;Thy1-GFP+/− mice.

(e) Reduction in the total number of branchpoints of basal dendrites in Zdhhc8+/−;Thy1-GFP+/− and Zdhhc8−/−;Thy1-GFP+/− CA1 hippocampal neurons.

(f) Sholl analysis of dendritic complexity. Analysis of the interaction between branchpoints and distance from the soma shows an overall genotype effect (n = 36, P < 0.01). Data are shown as mean ± S.E.M. * P < 0.05, ** P < 0.001, *** P < 0.0001.