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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2009 Aug 6;29(10):1602–1607. doi: 10.1161/ATVBAHA.109.187393

Figure 2. The role of ApoER2 in platelet adhesion to FXI.

Figure 2

(A) Purified human platelets (2 × 107/ml) were pipetted onto surfaces coated with FXI or fibrinogen (FG) in the absence or presence of receptor-associated protein (RAP, 40 µg/ml) or soluble ApoER2’ (sApoER2’, 40 µg/ml), followed by incubation at 37°C for 45 min. (B) Additional adhesion experiments were performed on immobilized FXI in the presence of the LDL binding domains 1 or 2 of ApoER2 (BD1 or BD2, respectively, 40 µg/ml). Adherent platelets were analyzed for each suspension treatment and reported as adherent cells/mm2 × 10−2. Values are reported as mean ± SEM of three experiments. *P < 0.05 compared to adhesion on FXI in the presence of vehicle.