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. Author manuscript; available in PMC: 2010 Aug 1.
Published in final edited form as: Eur J Pharmacol. 2009 May 20;615(1-3):66–75. doi: 10.1016/j.ejphar.2009.05.008

Fig. 5. Effect of cyproheptadine or ketanserin on 5-HT efflux in the cortex.

Fig. 5

Rats were pretreated with clorgyline (CLG; 2 mg/kg, i.p.) 12 h before in vivo microdialysis. Open arrows indicate the time for injection of vehicle (veh), cyproheptadine (CPH; 10 mg/kg, i.p.) or ketanserin (ket; 5 mg/kg, i.p.), and solid arrows show the time for 5-HTP administration. Values are expressed as means ± S.E.M. There was a significant reduction in basal 5-HT in rats injected with cyproheptadine compared to the control (A). Injection of 10 mg/kg (B) or 25 mg/kg (C) 5-HTP produced a dose-dependent increase in 5-HT efflux in the cortex in the control groups. This effect was significantly reduced in rats pretreated with cyproheptadine or ketanserin. * P < 0.05 and ** P < 0.01 show significant differences between vehicle and cyproheptadine pretreatment, examined by the two-way factorial ANOVA followed by a post-hoc Scheffe test. The total accumulative increase in 5-HT efflux over 90 min in B and C was replotted in D as Area under the Curve (AUC). * P < 0.05 indicates significant differences between vehicle and cyproheptadine pretreatment, examined by unpaired t-test.