Table III.
Structure of the N-Me-2 Sub-Library
| Peptide Name | Ring Size | m | n | Origin |
|---|---|---|---|---|
| N-Me-2−1 | 20 | 2 | 2 | BL3020−1 |
| N-Me-2−2 | 21 | 3 | 2 | BL3020−4 |
| N-Me-2−4 | 22 | 4 | 2 | BL3020−10 |
| N-Me-2−5 | 23 | 5 | 2 | BL3020−9 |
| N-Me-2−6 | 21 | a | 2 | BL3020−17 |
| N-Me-2−7 | 21 | 2 | 3 | BL3020−8 |
| N-Me-2−8 | 22 | 3 | 3 | BL3020−6 |
| N-Me-2−9 | 22 | b | 3 | BL3020−16c |
| N-Me-2−10 | 22 | 4 | 3 | BL3020−15 |
| N-Me-2−11 | 23 | 5 | 3 | BL3020−7 |
| N-Me-2−12 | 23 | b | 3 | BL3020−17c |
| N-Me-2−13 | 22 | 2 | 4 | BL3020−11 |
| N-Me-2−14 | 23 | 3 | 4 | BL3020−12 |
| N-Me-2−15 | 23 | b | 4 | BL3020−16c |
| N-Me-2−16 | 24 | 4 | 4 | BL3020−13 |
| N-Me-2−17 | 25 | 5 | 4 | BL3020−14 |
| N-Me-2−18 | 26 | b | 4 | BL3020−17c |
a
The dicarboxylic acyl spacer (m) was replaced by dimethylglutaric acid spacer. An analytical Vydac C18 column (Vydac 218TP104) was used with a flow rate of 1.0 mL/min. The peptide purity (>95%) was determined by HPLC at a wavelength of 220 nm.
b
The dicarboxylic acyl spacer (m) was replaced by o-phthaloyl spacer.
c
There are differences from the structures at Table I on the ring size and N-methylation position.