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Structure of the Pre-Cyclic N-Me-3 Sub-Library
| Peptide Name | Ring Size | m | n | Origin |
|---|---|---|---|---|
| N-Me-3−1 | – | 2 | 2 | BL3020−1 |
| N-Me-3−3 | – | a | 2 | BL3020−16 |
| N-Me-3−4 | – | 4 | 2 | BL3020−10 |
| N-Me-3−10 | – | 4 | 3 | BL3020−15 |
| N-Me-3−11 | – | 5 | 3 | BL3020−7 |
| N-Me-3−16 | – | 4 | 4 | BL3020−13 |
The dicarboxylic acyl spacer (m) was replaced by o-phthaloyl spacer. An analytical Vydac C18 column (Vydac 218TP104) was used with a flow rate of 1.0 mL/min. The peptide purity (>95%) was determined by HPLC at a wavelength of 220 nm.
