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Functional Activity of N-Me-1 Library at the Mouse Melanocortin Receptors
| Ref | mMC1R (nM) | mMC3R (nM) | mMC4R (nM) | mMC5R (nM) |
|---|---|---|---|---|
| NDP-MSH | 0.0081 ± 0.001 | 0.063 ± 0.004 | 0.097 ± 0.016 | 0.078 ± 0.0084 |
| Compound 1 | 64 ± 14 | 770 ± 175 | 4.0 ± 0.6 | 7.0 ± 0.40 |
| N-Me-1−1 | 720 ± 397 | >100,000 | 100 ± 47 | 200 ± 35 |
| N-Me-1−2 | 743 ± 210 | >100,000 | 175 ± 96 | 392 ± 89 |
| N-Me-1−3 | 930 ± 156 | >100,000 | 96 ± 46 | 69 ± 13 |
| N-Me-1−4 | 12,680 ± 9150 | >100,000 | 1913 ± 878 | 820 ± 132 |
| N-Me-1−6 | 1490 ± 367 | >100,000 | 291 ± 127 | 1610 ± 727 |
