Table VII.

Functional Activity of N-Me-2 Library at the Mouse Melanocortin Receptors

Ref	mMC1R (nM)	mMC3R (nM)	mMC4R (nM)	mMC5R (nM)
NDP-MSH	0.0081 ± 0.001	0.063 ± 0.004	0.097 ± 0.016	0.078 ± 0.0084
Compound 1	64 ± 14	770 ± 175	4.0 ± 0.6	7.0 ± 0.40
N-Me-2−1	2510 ± 610	>100,000	4900 ± 1800	4540 ± 1400
N-Me-2−2	4100 ± 190	>100,000	2500 ± 330	1430 ± 565
N-Me-2−4	1196 ± 670	>100,000	2877 ± 659	2960 ± 995
N-Me-2−5	1049 ± 312	>100,000	2416 ± 498	7990 ± 460
N-Me-2−6	4900 ± 1030	>100,000	4350 ± 385	7010 ± 2900
N-Me-2−7	8220 ± 7500	>100,000	2710 ± 520	3500 ± 1125
N-Me-2−8	8670 ± 3340	>100,000	860 ± 110	900 ± 280
N-Me-2−9	6167 ± 2687	>100,000	872 ± 379	189 ± 28
N-Me-2−10	8175 ± 1970	>100,000	2493 ± 479	2115 ± 392
N-Me-2−11	6000 ± 4200	10,380 ± 2270	1050 ± 33	1160 ± 365
N-Me-2−12	8070 ± 2900	>100,000	4900 ± 3200	2420 ± 470
N-Me-2−13	4920 ± 1900	>100,000	1030 ± 109	2020 ± 350
N-Me-2−14	3440 ± 2890	>100,000	498 ± 67	740 ± 110
N-Me-2−15	2478 ± 1566	>100,000	1416 ± 922	605 ± 125
N-Me-2−16	5410 ± 2092	>100,000	1457 ± 731	1034 ± 129
N-Me-2−17	2340 ± 559	>100,000	1552 ± 845	1297 ± 100
N-Me-2−18	8440 ± 4495	>100,000	1850 ± 97	4590 ± 930