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Warfarin pharmacokinetic and pharmacodynamics pathway. Warfarin is administered as a racemic admixture of R and S enantiomers. The more potent S enantiomer is metabolized principally by Cytochrome P4502C9 (CYP2C9). The pharmacological effect of warfarin is mediated by the inhibition of Vitamin K epoxide reductase complex 1 (VKORC1). This results in the decreased concentrations of activated clotting factors (II, VII, IX and X) producing therapeutic anticoagulation.
