. Author manuscript; available in PMC: 2009 Oct 5.

Published in final edited form as: Pharmacotherapy. 2008 Sep;28(9):1084–1097. doi: 10.1592/phco.28.9.1084

Table 1.

CYP2C9 and VKORC1 allele frequencies among African Americans, European Americans, and Hong Kong Chinese

	Reference	Variant	Activity	African	European	Hong Kong
	Sequence			American^a	American^a	Chinese^b
	Number			(n=268)	(n=292)	(n=69)
CYP2C9
^*1	-	Wild Type	Normal
^*2	rs1799853	R144C (3608C→T)	Decreased	1.3%	12.8%
^*3	rs1057910	I359L (42614A→C)	Decreased	1.9%	6.3%	3%
^*5	rs28371686	D360E (42619C→G)	Decreased	0.93%	-	-
^*6	rs9332131	10601delA (818delA)	Null	0.75%	-	-
^*11	rs28371685	R335W (1003C→T)	Decreased	1.5%	-	-
VKORC1
1173C/T	rs9934438			10.6%	36.5%	87%
−1639G/A	rs9923231			10.9%	36.1%	87%

The 1 allele frequency is derived by subtracting the variant allele frequencies from 100%

Limdi et al (Pharmacogenomics, in press 2008)²⁴

Veenstra, et al, Pharmacogenetics and Genomics 2005²⁵