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Anti-viral efficacy of AZT and D-Carba T versus wild-type and select NRTI resistant HIV-1 viral vectors.
| D-Carba T (µM) |
AZT (nM) |
||
|---|---|---|---|
| HOS | 313 | HOS | |
| Wild-type | 3.2 ± 1.7 | 0.83 ± 0.21 | 1.4 ± 0.1 |
| M184V | 1.8 ± 1.0 | 0.19 ± 0.03 | 3.6 ± 0.3 |
| AZT-R | 1.3 ± 0.4 | 0.87 ± 0.13 | 20.1 ± 1.8 |
| SSGR + T215Y | 4.6 ± 1.2 | 1.0 ± 0.1 | 39.6 ± 7.7 |
