FIG. 6.

Cumulative immune mediator expression by CD8⁺ and CD4⁺ T cells to HIV-1 Gag and Nef peptide pools as determined by ICS. The bars represent cumulative data on percentages of IL-2, IFN-γ, TNF-α, MIP-1β, and CD107a produced by T cells from HIV-1-infected subjects on ART (n = 5 subjects; <50 copies/ml HIV-1 RNA) in response to the Gag and Nef peptide pools (5 μg/ml). The data show that there were no differences in production of the immune mediators by CD4⁺ and CD8⁺ T cells stimulated by the various Gag pools (A and C) and a trend of lower T-cell responses to the larger Nef peptide pools (B and D) (P = NS).