TABLE 1.

Clinical and laboratory findings in patients with proven or probable coccidioidomycosis^a

Patient no.	Underlying condition	Presentation	Clinical and laboratory findings
			Positive cultureb	Pathology	Serology	Urine antigen testing (ng/ml)	Serum antigen testing (ng/ml)	Serum antigen EDTA testing (ng/ml)
1	Unk	CNS	Unk	Unk	Unk	0.14	0.09	4.42
2	Unk	CNS	Unk	Unk	EIA IgM Pos, IgG Pos	Neg	Neg	Neg
3	Cirrhosis corticosteroid	Pulmonary, fatal	BAL specimen	Unk	EIA IgM Pos, IgG Neg	Neg	Neg	Neg
4	Unk	Unk	Unk	Unk	Unk	Not done	0.09	3.28
5	None	Pulmonary, chronic cavitary	BAL specimen	Neg	CF of 16	Neg	Neg	Neg
6	Unk	Disseminated	Ear	Unk	Unk	3.13	3.82	>8.2
7	Unk	Disseminated, fatal	Unk	Unk	Unk	3.43	8.03	>8.2
8	Heart transplant	Pulmonary, fungemia, fatal	Blood sample	Not done	EIA IgM Neg, IgG Pos	3.42	Neg	0.07
9	None	Disseminated, bone, soft tissuec	Soft tissue	Unk	Unk	5.06	>8.2	>8.2
10	Unk	Unk	Unk	Unk	Unk	0.48	0.18	0.28
11	Unk	Unk	Unk	Unk	Unk	0.15	Neg	0.73
12	Unk	Unk	Unk	Unk	Unk	Not done	Neg	0.77
13	Metabolic syndrome	Pulmonary	Sputum, BAL specimen	Not done	EIA IgM Pos, IgG Pos, CF of 8	Neg	Neg	1.33
14	HIV	Asymptomatic	Not done	Not done	IgM Neg, IgG Pos, CF Neg	Not done	Neg	0.25
15	Unk	Pulmonary, disseminated	Skin	Skin	EIA IgM Pos, IgG Pos, CF of 256	0.80	Neg	0.65
16	Unk	Pulmonary, disseminated, bone	Not done	Not done	EIA IgM Neg, IgG Pos, CF of 128	Neg	Neg	Neg
17	Diabetes, hypertension	Pulmonary, disseminated, prostatec	Seminal fluid	Not done	CF of 4	Neg	Neg	Neg
18	None	Disseminated, soft tissue	Not done	Not done	EIA IgM Neg, IgG Pos, IDCF Pos, IDTP Neg, CF of 256, CSF CF Neg	Not done	Neg	0.29
19	None	Pulmonary, disseminated, bonec	Not done	Not done	CF of 4	Neg	Neg	0.20
20	None	Disseminated, fatal	CSF, bone	Not done	CF of 128, CSF CF of 8	5.68	6.99	>8.2
21	AIDS	Pulmonary	Not done	Not done	CF of 128	0.88	0.26	0.88
22	AIDS	Pulmonaryd	Not done	Not done	EIA IgM Neg, IgG Pos	Neg	Neg	Neg
23	HIV	Pulmonarye	Not done	Not done	EIA IgM Neg, IgG Pos	Neg	Neg	Neg
24	AIDS	Pulmonaryf	Not done	Not done	Not done	0.11	Neg	Neg
25	AIDS	Pulmonary, disseminated, CNS	Not done	Not done	EIA IgM Neg, IgG Pos, CF of 256, CSF CF of 128	0.08	Neg	0.21
26	HIV	Pulmonary	Not done	Not done	EIA IgM Neg, IgG Pos, CF Neg	Neg	Neg	Neg
27	AIDS	Pulmonary	Not done	Not done	CF of 128	Neg	Neg	0.66
28	AIDS	Pulmonary, disseminated, lymph nodes	Not done	Not done	EIA IgM Neg, IgG Pos, CF of 2	Neg	Neg	0.16

^aPatients with proven coccidioidomycosis, n = 9; patients with probable coccidioidomycosis, n = 19. Abbreviations: CNS, central nervous system; BAL, bronchoalveolar lavage; CSF, cerebrospinal fluid; Neg, negative; Pos, positive; Unk, unknown; CF, reciprocal complement fixation titer; IDCF, immunodiffusion assay for complement-fixing antibody; IDTP, immunodiffusion assay for tube precipitin antibody.

^bIndication of a specimen type denotes that Coccidioides was isolated from that specimen.

^cRelapse, culture, sputum, bone, and lymph node samples were positive during initial infection.

^dDiagnosis of coccidioidomycosis as the cause of lung nodules was uncertain because of melanoma.

^eCulture proven to be pulmonary coccidioidomycosis 5 years earlier.

^fOriginal diagnosis 2 years earlier; presented with presumed pulmonary relapse, which responded to fluconazole.