FIG. 6.

Long imperfect direct repeats border the template region of telomerase RNAs from multiple yeast species. Shown are template regions of telomerase RNAs from a variety of yeast species. Terminal repeats of the template are shown underlined. Nonidentical bases within the repeats are indicated by gaps while missing bases (relative to the other repeat) are indicated by carets. S. cerevisiae has three possible pairs of direct repeats, as indicated. The second pair in S. cerevisiae as well as the pair of direct repeats in C. guilliermondii is shown in two independent lines in the figure because of their overlap. The yeast species are shown next to an approximate phylogenetic tree based on previous studies (2, 10, 18, 21). The templates are aligned according to the region encoding the expected Rap1 binding site of the telomeric repeat (shaded gray). In some species, the Rap1 binding site is encoded by two discontinuous parts of the template, which are copied into consecutive Rap1 binding sites in tandem telomeric repeats.