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Model of hnRNP A1 cooperative binding. 1, hnRNP A1 binds to the ESS, MS2 coat protein binds to the MS2 hairpin, and SC35 binds to the ESE. 2 and 3, hnRNP A1 cooperative spreading displaces bound MS2 coat protein. 4 and 5, hnRNP A1 unwinds MS2 hairpin and continues cooperative spreading. 6 and 7, hnRNP A1 cooperative spreading displaces bound SC35 from the ESE and inhibits splicing.
