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The bait and switch hapten 1 used to generate antibodies for the catalysis of the cyclization–cleavage of anhydroribitol phosphosphodiester 2. Below are juxtaposed the oxorhenium(v) metallochelate 3 used as a transition state analog (TSA) hapten to elicit antibodies that catalyzed the same cyclization cleavage of phosphodiester 4 (11).
