Fig. 5.
Effects of surgery on performance of adult and aged mice during reversal testing in the Morris water maze. (A) Aged mice that underwent surgery spent significantly more time perseverating in the old target quadrant than adult mice that underwent the same procedure. (B) In addition, aged surgical mice spent significantly less time in the new target quadrant compared to their age-matched controls. Data are represented as means ±S.E.M. Means with * are significantly different (p <0.05).