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. Author manuscript; available in PMC: 2009 Oct 5.
Published in final edited form as: Expert Opin Biol Ther. 2008 Feb;8(2):213–220. doi: 10.1517/14712598.8.2.213

Figure 3. Antitumor effect of MV-CEA, administered intratumorally in an orthotopic U87 tumor model.

Figure 3

Tumors were established by injection of 106 U87 cells into the right caudate nucleus of BALB/c nude mice. Mice were randomly assigned to either MV-CEA treatment (1.8 × 106 TCID50), UV-inactivated MV-CEA treatment, or remained untreated. Significant prolongation of survival was observed in the mice treated with MV-CEA, as compared to mice that received UV-inactivated MV-CEA or no treatment (p = 0.02).

Reproduced with permission from Phuong L, et al. Cancer Res 2003 [17].

CEA: Carcinoembryonic antigen; MV: Measles virus;

TCID50: Tissue culture infective dose.