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. Author manuscript; available in PMC: 2009 Oct 5.

Published in final edited form as: Ann Intern Med. 2008 Nov 4;149(9):601–611. doi: 10.7326/0003-4819-149-9-200811040-00003

APPENDIX TABLE 4.

EFFECTS OF TREATMENT ON BONE MINERAL DENSITY

			BASELINE		6 MONTHS			12 MONTHS
			Mean (SD)	minimum-maximum	Mean Change ^*	95% CI	P Value MK-677 vs. Placebo ^†	Mean Change ^*	95% CI	P Value MK-677 vs. Placebo ^†
BONE MINERAL DENSITY
Femoral Neck, g/cm²	Placebo	N=22	0.752 (0.137)	0.584-1.101	0.010	-0.001-0.021		0.012	0.002-0.022
	MK-677	N=43	0.748 (0.133)	0.522-1.066	-0.003	-0.011-0.005	0.079	-0.005	-0.01-0.002	0.004
Spine [L2-L4], g/cm²	Placebo	N=22	1.046 (0.164)	0.770-1.441	0.004	-0.013-0.022		0.005	-0.010-0.020
	MK-677	N=43	1.085 (0.196)	0.761-1.630	0.001	-0.012-0.013	>.99	0.008	-0-0.019	0.69
Total Hip, g/cm²	Placebo	N=22	0.910 (0.160)	0.688-1.315	0.005	-0.003-0.014		0.005	-0.003-0.013
	MK-677	N=43	0.896 (0.138)	0.686-1.183	-0.002	-0.008-0.004	0.22	-0.004	-0.01-0.002	0.063

Baseline data presented are the arithmetic mean (SD) and the minimum and maximum values

^*

Mean change (arithmetic difference) from baseline with 95% confidence limits at 6 months and at 12 months

^†

P values are for the pivotal comparisons between the two groups at 6 months and at 12 months.

Bone mineral density was determined by DXA.