APPENDIX TABLE 6.

EFFECTS OF TREATMENT ON FUNCTION

			BASELINE			6 MONTHS				12 MONTHS
			Mean (SD)	minimum-maximum		Mean Change *	95% CI	P Value MK-677 vs. Placebo †		Mean Change *	95% CI	P Value MK-677 vs. Placebo †
FUNCTION TESTS
30 m walk, sec	Placebo	N=21	14.5 (2.8)	9.5-21.2	N=21	-0.1			N=21	0.2
	MK-677	N=40	14.3 (2.9)	9.0-20.5	N=40	-0.3			N=40	-0.2
30 m walk, m/sec	Placebo	N=21	2.14 (0.40)	1.42-3.17	N=21	0.04			N=21	-0.01
	MK-677	N=40	2.19 (0.47)	1.46-3.32	N=40	0.05			N=40	0.06
30 m walk/TASM, sec/kg ‡	Placebo	N=21	0.89 (0.39)	0.36-1.64	N=21	-0.01	-0.04 - 0.03		N=21	0.01	-0.02 - 0.04
	MK-677	N=40	0.88 (0.33)	0.32-1.42	N=40	-0.01	-0.04 - 0.01	>.99	N=40	-0.01	-0.03 - 0.01	0.30
6 min walk, m	Placebo	N=20	422 (58)	267-534	N=19	8			N=20	5
	MK-677	N=40	426 (58)	334-567	N=40	9			N=40	11
6 min walk, # laps	Placebo	N=20	4.7 (0.7)	3.0-6.0	N=19	0.1			N=20	0.1
	MK-677	N=40	4.8 (0.7)	3.8-6.4	N=40	0.1			N=40	0.1
6 min walk, # laps/TASM ‡	Placebo	N=20	0.28 (0.08)	0.15-0.41	N=19	0.004	-0.004-0.013		N=20	0.002	-0.005-0.009
	MK-677	N=40	0.28 (0.06)	0.16-0.45	N=40	0.005	-0.001-0.011	>.99	N=40	0.006	0.001-0.011	0.44
Sit-Stand x 5, sec	Placebo	N=17	11.0 (2.8)	7.4-18.2	N=17	-0.6			N=17	-0.1
	MK-677	N=30	11.2 (2.2)	7.3-16.6	N=30	-0.6			N=30	-0.3
Sit-Stand x 5/TASM, sec/kg ‡	Placebo	N=17	0.70 (0.31)	0.27-1.3	N=17	-0.04	-0.10 - 0.02		N=17	0.00	-0.06 - 0.05
	MK-677	N=30	0.68 (0.23)	0.26-1.04	N=30	-0.04	-0.09 - 0.01	>.99	N=30	-0.03	-0.07 - 0.01	0.37
FUNCTION TESTS
Stairs - DOWN, sec	Placebo	N=19	16.6 (3.7)	12.5-27.5	N=19	0.1			N=19	0.4
	MK-677	N=38	17.7 (4.8)	10.7-32.2	N=38	-0.3			N=38	-0.3
Stairs -DOWN/TASM, sec/kg ‡	Placebo	N=19	1.0 (0.5)	0.4-1.9	N=19	0.01	-0.05 - 0.07		N=19	0.03	-0.03 - 0.08
	MK-677	N=38	1.1 (0.5)	0.4-2.0	N=38	-0.02	-0.07 - 0.02	0.91	N=38	-0.03	-0.06 - 0.01	0.180
Stairs - UP, sec	Placebo	N=20	17.9 (4.1)	12.7-29.6	N=20	0.0			N=20	0.2
	MK-677	N=39	19.4 (4.9)	10.8-31.9	N=39	0.1			N=39	0.3
Stairs - UP/TASM, sec/kg ‡	Placebo	N=20	1.09 (0.49)	0.44-2.06	N=20	-0.01	-0.06 - 0.05		N=20	0.02	-0.03 - 0.07
	MK-677	N=39	1.20 (0.51)	0.36-2.09	N=39	0.01	-0.03 - 0.05	>.99	N=39	0.02	-0.02 - 0.05	0.97

Baseline data presented are the arithmetic mean (SD) and the minimum and maximum values; N for each test is indicated.

^*Mean change (arithmetic difference) from baseline with 95% confidence limits at 6 months and at 12 months

^†P values are for the pivotal comparisons between the two groups at 6 months and at 12 months.

^‡Function variables were analyzed per kg TASM at baseline.

Empty cells = no statistical analyses were performed; raw data are reported in typical units for comparison

TASM = total appendicular skeletal muscle mass from DXA