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. Author manuscript; available in PMC: 2010 Jul 10.
Published in final edited form as: Cell. 2009 Jul 10;138(1):172–185. doi: 10.1016/j.cell.2009.04.031

Figure 5. MRF CKOs display a loss of mature OLs.

Figure 5

(A) Immunostaining for MBP, CC1, NG2, GFAP and Olig2 co-stained with CC1 and PDGFRα within the optic nerves of control (MRFwt/fl; Olig2wt/cre and MRFfl/fl; Olig2wt/wt) and MRF CKO (MRFfl/fl; Olig2wt/cre) mice at P13. Scale bar=50um. (B) Quantification of the density of Olig2 immunopositive nuclei within the optic nerves. (C) Quantification of the density of Olig2+/CC1+ double-immunopositive OLs within the optic nerves. (D) Quantification of the density of Olig2+/PDGFRα+ double-immunopositive OPCs within the optic nerves. All results are expressed as means ±SEM, n=4-5 per genotype. *P<0.05, **P<0.01. (E) Densities of Olig2 immunopositive cells within the optic nerves of each genotype broken down into Olig2+ cells also positive for either CC1 (OLs), PDGFRα (OPCs) or neither marker.