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. Author manuscript; available in PMC: 2010 Feb 15.
Published in final edited form as: J Immunol. 2009 Feb 15;182(4):1940–1953. doi: 10.4049/jimmunol.0800443

Figure 7. L5178Y cell-mediated priming of Mϕ involves engagement of CD40, NKG2D, and CD18 on Mϕ.

Figure 7

Naïve Mϕ from syngeneic DBA/2 mice were cultured for 24 hr alone or with L5178Y cells in medium with or without LPS and in the presence of either control isotype-matched IgG or blocking mAbs against CD154, NKG2D, CD18, and MHC-I, used alone or in various combinations. Results are presented as concentration of NO metabolites (µM) in the cell culture supernatants (A) or % of inhibition of 3H-TdR incorporation into L5178Y lymphoma cells (B). *-negligible values. N/T-not tested. The experiments are representative of three separate experiments with similar results. †p=0.00064; ‡p>0.05; §p=0.00031 The symbols † corresponds to p value of αCD40 treatment bar compared to control IgG treatment bar; symbols ‡ correspond to p value of either combined treatment bars compared to αCD40 treatment bar; symbols § correspond to p values of αCD40+αCD18+αNKG2D or αCD40+αCD18+αNKG2D+αMHC-I treatments compared to any other combined treatments.