Table 2.
Group | TBI Dose (cGy) |
Source of Cells | No of Dogs |
Survival (days) |
Causes of Death | Reference | |||
---|---|---|---|---|---|---|---|---|---|
Studied | Sustained Grafts |
Acute GVHD |
Range | Median | |||||
8 | 920 | Marrow/BC | 6 | 6 | 6 | 8–13 | 10.5 | ET1; GVHD | [10] |
9 | 920 | GPBMC ± SCF | 9 | 9 | 9 | 7–12 | 7 | ET1; GVHD | [8] |
10 | 450 | GPBMC | 6 | 1 | 1 | 13–80 | 21 | ET1; GVHD(n=1) ET1 (n=2) ET2 (n=2) Pneumonia (n=1) |
[9] |
Abbreviations: BC, buffy coat; ET1, euthanized, poor condition; ET2, euthanized, end of study; GPBMC, GCSF mobilized PBMC; SCF, stem cell factor.