Table 3.

Relative risks of clinical recurrence without and with adjustment for post-therapy PSA dynamics.

		Without adjustment for post-radiation PSA					With adjustment for post-radiation PSA
		UM	RTOG9 406	PMCC	WBH	Pooled	UM	RTOG9 406	PMCC	WBH	Pooled
Initial PSA		1.38	1.28	0.89	1.68	1.47	0.76	0.74	0.38	0.83	0.79
T-stage*	3 or 4	3.24	1.21	3.30	1.05	1.94	1.78	1.18	1.98	0.95	1.39
Gleason Score†	7	2.92	1.98	3.30	1.72	2.11	2.07	2.23	1.54	1.40	1.62
	8–10	2.78	1.79	1.76	1.45	1.66	2.01	1.09	1.84	0.97	1.16
Salvage ADT		1.42	4.11	4.03	0.72	1.09	0.35	0.55	0.37	0.29	0.33
PSA(t)††							1.64	1.58	1.85	1.56	1.58
Rate of PSA (t) change§							2.32	1.73	3.99	3.34	2.93

Bold underlined highly significant p<0.001; bold significant p in [0.001,0.05]; : not significant p>0.05.

^*Reference level T-stage 1--2

^†Reference level Gleason score 2--6

^††PSA(t) gives the relative risk (RR) of recurrence associated with an increase of 0.1 in the rescaled logistic link function of log(PSA+0.1) at current time

^§Rate of PSA(t) change gives the RR of recurrence associated with an unit-increase of rate of change of log(PSA+0.1) at current time