Table 2.
Table 2A. Oxidant response (EC50 measurements) in WEHI7.2 cells treated with MnTE-2-PyP5+ | ||
---|---|---|
Treatment | H2O2 (µM) |
Paraquat (µM) |
Control | 104.9 ± 5.4 | 44.6 ± 1.3 |
0.75 µM MnTE-2-PyP5+ | 102.8 ± 6.7 | 59.8 ± 1.6* |
1.5 µM MnTE-2-PyP5+ | 61.7 ± 1.7* | 63.7 ± 6.0* |
Table 2B. Chemotherapeutic drug response (EC50 measurements) of WEHI7.2 cells pre-treated with MnTE-2-PyP5+ | |||
---|---|---|---|
Treatment | Cyclophosphamide (mM) |
Doxorubicin (nM) |
Vincristine (nM) |
Control | 2.25 ± 0.10 | 10.3 ± 0.9 | 2.1 ± 0.1 |
0.75 µM MnTE-2-PyP5+ | 1.07 ± 0.08* | 9.6 ± 0.3 | 2.3 ± 0.2 |
1.5 µM MnTE-2-PyP5+ | 0.73 ± 0.04* | 10.3 ± 0.2 | 1.9 ± 0.2 |
denotes significantly different from untreated WEHI7.2 (control) cells (p ≤ 0.05). Values represent the mean ± S.E.M.; n = 3.
denotes significantly different from untreated WEHI7.2 (control) values (p ≤ 0.05). Values represent the mean ± S.E.M. (n=3 or 4).