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. 2009 Jul 21;284(37):24933–24938. doi: 10.1074/jbc.C109.024083

FIGURE 1.

FIGURE 1.

Fast inactivation of ORAI1 currents is preserved as long as CMD is present in STIM1. a, b, d, and e, fast inactivation of STIM1- (a), STIM1-(1–474)- (b), STIM1-(1–485)- (d), and STIM1 7xA-mediated (e) ORAI1 Ca2+ currents upon voltage steps from a holding potential of 0 mV to −30, −50, −70, and −90 mV. c and f, mean fast inactivation of normalized current traces of STIM1, STIM1-(1–535), STIM1-(1–485), STIM1-(1–474), and STIM1 7xA upon voltage steps to −90 mV. g, scheme of various STIM1 deletion mutants (STIM1, STIM1-(1–535), STIM1-(1–485), STIM1-(1–474), STIM1-(1–450)) as well as STIM1 7xA and EF-hand mutant STIM1 D76A in comparison with the extent of inactivation of ORAI1 currents at t = 90 ms (p < 0.05 for STIM1 when compared with STIM1-(1–474), STIM1-(1–450), and STIM1 7xA) and maximum current densities. wt, wild type; SAM, sterile α motif; TM, transmembrane; pA, picoampere; pF, picofarad.