FIGURE 3.

Constitutive activation of ERK5 inhibits wound healing and cell motility. A, MEK5DD-expressing HUVEC do not migrate into the artificially induced wounded area on a gold electrode as indicated by the missing recovery impedance values after electric wounding of the monolayer. Normalized impedance at a sampling frequency of 40 kHz of three independent experiments is depicted. B, cell micromotion, detected by fluctuation of resistance (4 kHz) over time, is reduced in MEK5DD-expressing HUVEC. C, quantitative analysis of EC micromotion. The bars show the average S.D. of increments for consecutive data frames of 64 s. a.u., arbitrary units.